Before setup your outlook 2010, please make sure you have below information incoming mail server : mail yourdomain.com
outgoing smtp server : smtp.yourdomain.com
email address : firstname.lastname@example.org
password : *****************
Open Outlook 2010
Click "File" then "+Add Account"
Choose "Manually configure server settings or additional server types" then next
Choose "Internet E-Mail" then next
Enter all information then click "More setting"
Choose "My outgoing server (SMTP) required authentication"
Make sure correct port number has entered for both POP3 and SMTP then OK
(If you would like to keep a copy on server, please select "Leave a copy of message on the server" then OK)
If there has no problem, the below screen should come up